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LUCINDA Study
LUCINDA is a randomized double-blind, placebo-controlled trial of Lupron and donepezil in women with mild to moderate Alzheimer’s disease.
The goal of LUCINDA is to learn whether an existing injectable medication (Leuiprolide) may be effective against Alzheimer’s Disease to improve activities of daily living and cognition.
The study is a 3-site study included University of Miami Comprehensive Center for Brain Health, Weill Cornell Medicine in NY, and University of Wisconsin. LUCINDA is supported by a grant from the National Institutes of Health.
ClinicalTrials.gov:NCT03649724
IRB APPROVED 02/20/2024
What is Leuprolide currently prescribed for? Leuprolide is approved by the FDA for treatment of prostate cancer in men, endometriosis in women and early puberty in children. It is also commonly used in women preparing for in vitro fertilization. LUCINDA aims to repurpose Leuprolide for Alzheimer’s Disease.
Who can join this study? This
study is open to women 60 years and older diagnosed with Alzheimer’s
Disease who are taking a stable
dose of the medication donepezil
(Aricept.) Participants must have a
study partner (friend or family
member) who can accompany
them to all study visits.
Will it cost me anything to be in
this study?
No. You will be compensated for
your time and effort.
For study interest, please contact the Lucinda Study Coordinator, Adolfo Henriquez, at amh122@miami.edu.