Active Studies

Healthy Brain Initiative (HBI)

Healthy Brain Initiative Project is funded by multiple federally funded and private grants:

  • R01 NS101483-01A1 Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural Population
  • R01 AG071514-01 Multicultural Community Dementia Screening

HBI is an ongoing project that is actively recruiting community-dwelling independent adults with no complaints or mild concerns about their brain health. This project aims to develop a dementia prevention initiative using a precision medicine approach with personalized tailored interventions in deeply phenotyped individuals.

You must have a study partner (This is a person who knows you well such as a spouse, adult child, best friend who can answer questions about your memory and thinking abilities). The Study Partner can participate in-person, Zoom, or by phone. You also should be willing to do a blood draw or saliva collection, and undergo testing and imaging procedures (e.g., MRI and/or PET).


Mary Lou Riccio,

Inclusion Criteria:

  • Adults >25 years of age (with a target population of 50 and above). 
  • Individuals with:  NO cognitive impairment ; subjective cognitive impairment ; mild cognitive impairment  ; any cause of dementia or neurodegenerative disease at the mild stage 
  • Must have a study partner 
  • Individuals recruited should be medically eligible to undergo MRI and/or PET however, those who are not, may still participate in the study

Exclusion Criteria:

Individuals who: 

  • DO NOT consent to have their data or specimens stored 
  • Have already been diagnosed with moderate or severe ADRD (CDR 2 or greater) or cannot contribute clinical, cognitive, behavioral, or functional data Have significant medical illness: Any significant systemic illness or unstable medical condition occurring during source cohort participation that could affect participation in imaging or obfuscate relevant cognitive outcomes. This can include (but is not limited to):
    • Metastatic cancer
    • Primary Axis I disorder (schizophrenia, major depressive disorder, bipolar disorder) or Axis II personality disorder
    • Unstable diabetes or hypertension
    • Substance abuse within the past 5 years