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Healthy Brain Initiative (HBI) Study

Study flyer

HBI is an observational, ongoing study actively recruiting community-dwelling adults with no complaints or mild concerns about their brain health. This project aims to develop a dementia prevention initiative using a precision medicine approach with personalized tailored interventions in deeply phenotype individuals.

Study participants must have a study partner (This is a person who knows the participant well such as a spouse, adult child, or best friend who can answer questions about memory and thinking abilities). The study partner may participate in-person, by phone, or Zoom. Participants must be willing to do a blood draw or saliva collection, questionnaires, physical assessment, and imaging procedures (e.g., MRI and/or PET).

Inclusion Criteria

Individuals who:

      • Adults >50 years and older.
      • Individuals with either no cognitive impairment, subjective cognitive impairment, mild cognitive impairment , any cause of dementia or neurodegenerative disease at the mild stage.
      • Must have a study partner.
      • Participants should be medically eligible to undergo MRI and/or PET.

Exclusion Criteria

Individuals who:

      • Do not consent to have their data or specimens stored.
      • Have already been diagnosed with moderate or severe ADRD (CDR 2 or greater) or cannot contribute clinical, cognitive, behavioral, or functional data.
      • Have significant medical illness.
      • Any significant systemic illness or unstable medical condition occurring during source cohort participation that could affect participation in imaging or obfuscate relevant cognitive outcomes. This can include (but is not limited to):
      • Metastatic cancer
      • Primary Axis I disorder (schizophrenia, major depressive disorder, bipolar disorder) or Axis II personality disorder
      • Unstable diabetes or hypertension
      • Substance abuse within the past 5 years

Healthy Brain Initiative Project is funded by multiple federally funded and private grants:

  • R01 NS101483-01A1 Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural Population
  • R01 AG071514-01 Multicultural Community Dementia Screening

To learn more about our HBI study or other interests, please complete the form below or call us at 561-869-6828.

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